Click chemistry as a connection tool: Grand opportunities and challenges

Although the concept of click chemistry was proposed more than twenty years ago, research progress has emerged with great vitality, and this year's Nobel Prize in once again highlighted importance field chemistry. Click is a reaction which variety molecules are quickly reliably synthesized by piecing together small units. In particular, it emphasizes development new combinatorial methods based on synthesis carbon-heteroatomic bonds simple efficient acquisition molecular diversity through these reactions. Based superior characteristics chemistry, for production advancing toward precision, simplicity, high returns, especially producing polymer materials some bright biomedical applications. Here, we describe logic typical reactions different substrates catalysts. The latest technologies structure control functional properties polymers, as well biomedicine its expanding applications, discussed. Finally, identify challenges mechanisms engineering suggest potential future directions future.